Minimax optimization for handling range and setup uncertainties in proton therapy

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Minimax optimization for handling range and setup uncertainties in proton therapy.

PURPOSE Intensity modulated proton therapy (IMPT) is sensitive to errors, mainly due to high stopping power dependency and steep beam dose gradients. Conventional margins are often insufficient to ensure robustness of treatment plans. In this article, a method is developed that takes the uncertainties into account during the plan optimization. METHODS Dose contributions for a number of range ...

متن کامل

Site-specific range uncertainties caused by dose calculation algorithms for proton therapy.

The purpose of this study was to assess the possibility of introducing site-specific range margins to replace current generic margins in proton therapy. Further, the goal was to study the potential of reducing margins with current analytical dose calculations methods. For this purpose we investigate the impact of complex patient geometries on the capability of analytical dose calculation algori...

متن کامل

Dose uncertainties in IMPT for oropharyngeal cancer in the presence of anatomical, range, and setup errors.

PURPOSE Setup, range, and anatomical uncertainties influence the dose delivered with intensity modulated proton therapy (IMPT), but clinical quantification of these errors for oropharyngeal cancer is lacking. We quantified these factors and investigated treatment fidelity, that is, robustness, as influenced by adaptive planning and by applying more beam directions. METHODS AND MATERIALS We us...

متن کامل

Uncertainties in minimax stochastic programs

When using the minimax approach one tries to hedge against the worst possible distribution belonging to a specified class P . A suitable stability analysis of results with respect to the choice of this class is an important issue. It has to be tailored to the type of the minimax problem, to the considered class of probability distributions and to the anticipated input perturbations. We shall fo...

متن کامل

Handling variations and uncertainties

DRASTIC DEVICE SHRINKING, lower power supply levels, and increasing operating speeds significantly reduce noise margins and increase variations in process, device, and design parameters. These trends lead to lower reliability and higher design uncertainty for hardware components. With further technology scaling, high variability and low reliability are bound to become the predominant challenges...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Medical Physics

سال: 2011

ISSN: 0094-2405

DOI: 10.1118/1.3556559